PolysacDB Glycopeptidolipid antigen 1672
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Glycopeptidolipid antigen
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Mycobacterium avium complex serovar 8
[edit] Basic Structure
This antigen is composed of a glycosylated lipopeptide core, fatty acyl-D-phenylalanine-D-allothreonine-D-alanine-L-alaninyl-O-(3,4-di-O-methyl-α-L-rhamnopyranoside), to which a haptenic oligosaccharide is linked at the threonine substituent
[edit] Proposed functions
This oligosaccharide unit is the source of the dominant immunogenicity of members of the M. avium complex, i.e., their characteristic agglutinability and type specificity
[edit] Antigenic Nature used to produce antibodies
whole cells combined with whole unfractionated lipid
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 2B8
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA, Inhibition assays, dot blot
[edit] Cross-reactivity
This antibody cross-reacted with whole cells of serovar 8, acetylated-GPL-8, and GPL-8
[edit] Proposed epitopes
4,6-(l'-carboxyethylidene)-3-0-methyl-beta-D-glucopyranosyl residues seemed to be a part of the epitope
[edit] Proposed Utility
This Mab can be used for the identification and classification of M. avium isolates. This Mab can be applied directly to bacterial cultures, thus allowing easy, rapid identification of at least half of the M. avium isolates encountered in the clinical laboratory
