PolysacDB Glucan 1042

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Glucan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Neurospora crassa

[edit] Basic Structure

Glucans are a heterogeneous group of glucose polymers, consisting of a backbone of β(1-->3)-linked β-D-glucopyranosyl units with β(1-->6)-linked side chains of varying distribution and length

[edit] Proposed functions

Activates leukocytes, stimulating their phagocytic, cytotoxic, and antimicrobial activities, including the production of reactive oxygen and nitrogen intermediates

[edit] Antigenic Nature used to produce antibodies

Homogenous suspension of hyphal walls.

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

S4D1

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, immunofluorescence

[edit] Cross-reactivity

This antibody was cross-reactive with A.nidulans, Schiz.commune.

[edit] Proposed epitopes

1,3-α-glucan

[edit] Proposed Utility

Screening of fungi for presence of 1,3-α-glucan in hyphae cell wall.

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database