PolysacDB Core oligosaccharide 2292
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Core oligosaccharide
[edit] Carbohydrate Class
Core oligosaccharide [LPS]
[edit] Source Microbe
Shigeila sonnei serotype D
[edit] Basic Structure
Lipopolysaccharide (LPS) molecules consist of three structural regions: a lipid A region, which anchors the molecule in the bacterial outer membrane; an intermediate core region; and a distal, serotype-specific O-polysaccharide chain (O chain or O-antigen). Whereas the chemical composition and structure of 0 chains are highly variable, the core moiety is more conserved. Seven types of LPS core structures, namely, Ra, Ri to R4, K-12, and B, have been found in members of the family Enterobacteriaceae
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Heat killed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab Sh9R
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA and immunoblotting
[edit] Cross-reactivity
only strains reported to have LPS molecules with an R1-type core structure were recognized, namely, S. sonnei, S. boydii type 3, S. flexneri type 6, a control E. coli R1 strain (HF4704), and an E. coli 09 isolate
[edit] Proposed epitopes
Terminal hexose residues may form an important part of the epitope
[edit] Proposed Utility
This Mab has been used to analyze clinical isolates and a hybrid Salmonella typhi strain for their expression of the corresponding LPS moieties. In addition to their use in the screening of candidate vaccine strains, the new MAb provide a powerful tool for epidemiological and phylogenetic studies of natural enterobacterial populations
