PolysacDB Core oligosaccharide 2220
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Core oligosaccharide
[edit] Carbohydrate Class
Core oligosaccharide [LPS]
[edit] Source Microbe
Salmonella typhimurium SL 1032 [Rd1]
[edit] Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : L-gro-α-D-manHepp-(1-->7)-L-gro-α-D-manHepp-(1-->3)-L-gro-α-D-manHepp-(1-->5)-α-Kdop [branched to α-Kdop-(2-->4)] -(2--/lipid A/
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Heat killed bacteria
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MAST27
[edit] Antibody type and class
IgG2b
[edit] Assay System
enzyme immunoassay, immunoblotting
[edit] Cross-reactivity
This Mab was specific to Rd1 chemotype
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab would help elucidate the LPS core domain structure
