PolysacDB Core oligosaccharide 2216
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Core oligosaccharide
[edit] Carbohydrate Class
Core oligosaccharide [LPS]
[edit] Source Microbe
Salmonella choleraesuis SN57 [Ra]
[edit] Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MASC1-MM3
[edit] Antibody type and class
IgM
[edit] Assay System
enzyme immunoassay, immunoblotting
[edit] Cross-reactivity
This Mab cross-reacted with with six different Salmonella core chemotypes S, Ra, Rb1, Rb2, Rb3, Rc and Rd1, the R2 core of Escherichia coli and a variety of smooth LPS
[edit] Proposed epitopes
The terminal disaccharide L-α-D-Hep1-->7-L-α-D-Hep1-O-me seemed to be the immunodominant epitope
[edit] Proposed Utility
This Mab would help elucidate the LPS core domain structure
