PolysacDB Core oligosaccharide 2027
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Core oligosaccharide
[edit] Carbohydrate Class
Core oligosaccharide [LPS]
[edit] Source Microbe
Pseudomonas aeruginosa
[edit] Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Heat killed Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 73.5
[edit] Antibody type and class
IgG1
[edit] Assay System
ELISA, flow cytometry, immunoblotting and immunogold electronmicroscopy
[edit] Cross-reactivity
The Mab cross-reacted with some of the other Pseudomonas spp such as P . Acidovorans, P.fluorescens, P. mendocina, P . pseudoalkaligenes, P. putida and P . Stutzeri and P. testosteroni but not with P. cepacia or Xanthomonas (Pseudomonas) maltophilia
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab demonstrated opsonophagocytic killing of 06 subtype strains in the presence of human peripheral blood leukocytes and fresh human serum. This Mab also showed in vivo protection
