PolysacDB Capsular polysaccharides K5 1039
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharides K5
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Escherichia coli
[edit] Basic Structure
Capsular polysacchirides K5 is disaccharide with repeating unit 4-β-GlcUA(1-->4)-α-GlcNAc
[edit] Proposed functions
Capsular polysaccharides are responsible for pathogen`s virulence
[edit] Antigenic Nature used to produce antibodies
Whole formalinized E.coli cells.
[edit] Carrier Name
N/A
[edit] Conjugation Method
N/A
[edit] Antibodies
Mab 865
[edit] Antibody type and class
IgM
[edit] Assay System
Indirect ELISA, Immunoblot analysis
[edit] Cross-reactivity
This antibody was cross-reactive with ECA of E.coli and S.typhimurium strains.
[edit] Proposed epitopes
4-β-GlcUA(1-->4)-α-GlcNAc
[edit] Proposed Utility
Reaction pattern of Mab with whole cell bacteria indicate that ECA and outer core in encapsulated bacteria are not readily accessible to antibodies.This suggests that these common envelop structures may not be useful antigens for vaccine development.
