PolysacDB Capsular polysaccharide 1867
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Neisseria meningitidis group B
[edit] Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
[edit] Proposed functions
It is an important virulence factor
[edit] Antigenic Nature used to produce antibodies
Infected patient
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab VAN
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, Rat protection assay
[edit] Cross-reactivity
This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
[edit] Proposed epitopes
The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
[edit] Proposed Utility
This antibody protected infant rats from bacteremia caused by Escherichia coli K1
