PolysacDB Capsular polysaccharide 1832
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Escherichia coli K1 strain
[edit] Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
[edit] Proposed functions
It is an important virulence factor
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab HmenB1
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, flow cytometry and bactericidal assay
[edit] Cross-reactivity
This Mab cross-reacted with Neisseria meningitidis Group B capsular polysaccharide and EV36 which is an E. coli K-12 strain possessing the genes for K1 capsular polysaccharide production and expresses non-acetylated α (2-->8) polysaccharide just like Neisseria meningitidis group B capsular polysaccharide. This Mab also reacted on the surface of human neuroblastoma cell line, CHP-134
[edit] Proposed epitopes
α(2-->8)-linked units of N-acetylneuraminic acid residues seemed to be the part of the epitope
[edit] Proposed Utility
N/A
