PolysacDB Capsular polysaccharide 1807
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Neisseria meningitidis group B
[edit] Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
[edit] Proposed functions
It is an important virulence factor
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 30H12
[edit] Antibody type and class
IgG2a
[edit] Assay System
ELISA and bactericidal assays
[edit] Cross-reactivity
This Mab was specifc to Neisseria meningitidis group B and did not cross-react with group A and group C N. meningitidis capsular polysaccharides. This Mab did not recognized N-propionylated capsular polysaccharide of group B meningitidis
[edit] Proposed epitopes
α[2-->8] linked N-acetyl neuraminic acid residues seemed to be the part of the epitope
[edit] Proposed Utility
This Mab had potent bactericidal activity
