PolysacDB Capsular polysaccharide 1004
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Haemophilus influenzae
[edit] Basic Structure
A relatively simple antigen consisting of repeating units of 3-β-D ribose-(1-->1)-D-ribitol-5-phosphate
[edit] Proposed functions
An important virulence determinant
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Neisseria meningitidis group B outer membrane protein complex (Hib PS-OMP)
[edit] Conjugation Method
The strategy uses a oligopeptide spacer molecule whose parts are derived from both modified Haemophilus influenzae capsular polysaccharide and Neisseria meningitides group B outer membrane complex
[edit] Antibodies
Polysera
[edit] Antibody type and class
IgG1 and IgG2
[edit] Assay System
N\A
[edit] Cross-reactivity
N/A
[edit] Proposed epitopes
N\A
[edit] Proposed Utility
These antibodies exert their protective effect by initiating complement-mediated activities including opsonization and bacterial lysis
