Pasteurella multocida
From DrugPedia: A Wikipedia for Drug discovery
Pasteurella multocida
It is a Gram-negative, non-motile coccobacillus that is penicillin-sensitive and belongs to the Pasteurellaceae family.
| Kingdom | Bacteria |
|---|---|
| Phylum | Proteobacteria |
| Class | Gamma Proteobacteria |
| Order | Pasteurellales |
| Family | Pasteurellaceae |
| Genus | Pasteurella |
| Species | P. multocida |
| Binomial | Pasteurella multocida |
[edit] Pathogenic Activity
P. multocida is the most common cause of infection from animal injuries. In more serious cases, a bacteremia can result, causing an osteomyelitis or endocarditis. The bacteria may also cross the blood-brain barrier and cause meningitis.
[edit] Virulence
A bacteriophage encodes the toxin responsible for most P. multocida virulence factors. This toxin activates Rho GTPases, which bind and hydrolyze GTP, and are important in actin stress fiber formation. Formation of stress fibers may aid in the endocytosis of P. multocida. The host cell cycle is also modulated by the toxin, which can act as an intracellular mitogen.
