Papaverine
From DrugPedia: A Wikipedia for Drug discovery
| Papaverine
| |
| Systematic (IUPAC) name | |
| 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline chloride | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C20H21ClNO4- |
| Mol. mass | 374.83804 |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
[edit] Description
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
[edit] General Properties
*Molecular Weight
374.83804
*Molecular Formula
C20H21ClNO4-
*IUPAC NAME
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline chloride
*Canonical Smiles
COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC.[Cl-]
*Isomeric Smiles
N/A
*XLogP
N/A
*Topological Polar Surface Area
49.8
