Nystatin

From DrugPedia: A Wikipedia for Drug discovery

Pronouncation: (nye-STAT-in)

Class: Antifungal

Trade Names:

Mycostatin

- Vaginal tablets 100,000 units

- Ointment 100,000 units/g

- Powder 100,000ߙunits/g

Trade Names:

Mycostatin Pastilles

- Troches 200,000 units

Trade Names:

Nilstat

- Oral suspension 100,000 units

- Bulk powder 150 million units

- Bulk powder 1 billion units

- Bulk powder 2 billion units - Cream 100,000 units

- Ointment 100,000 units

Trade Names:

Pedi-Dri

- Powder 100,000 units/g

Candistatin (Canada)

Nyaderm (Canada)

PMS-Nystatin (Canada)

ratio-Nystatin (Canada)

Contents 1 Pharmacology 2 Indications and Usage 3 Contraindications 4 Dosage and Administration 5 Storage/Stability 6 See Also 7 References

[edit] Pharmacology

Binds to fungal cell membrane, changing membrane permeability and allowing leakage of intracellular components.

[edit] Indications and Usage

Treatment of intestinal, oral, vulvovaginal, cutaneous, or mucocutaneous candidiasis.

[edit] Contraindications

Standard considerations.

[edit] Dosage and Administration

Intestinal Candidiasis

Adults and Children

PO 500,000 to 1,000,000 units 3 times daily. Continue treatment for at least 48 h after clinical cure.

Oral or Mucocutaneous Candidiasis

Adults and Children

PO (suspension) 200,000 to 600,000 units 4 times daily; swish and swallow, or (oral pastilles) 1 to 2 pastilles (200,000 to 400,000 units) dissolved in mouth 4 to 5ߙtimes/day.

Infants

PO 200,000 units 4 times daily.

Vaginal Candidiasis

Adults

Intravaginal 100,000 units every day for 2 wk.

Cutaneous Candidiasis

Adults and Children

Topical Apply to affected areas twice daily to 3 times daily.

General Advice

• For troche/pastilles administration, have patient dissolve troche in mouth. Instruct patient not to chew or swallow troche whole. Have patient retain troche in mouth as long as possible before swallowing.

• For administration of oral suspension, place half of dose in each side of mouth. Have patient swish thoroughly around in mouth and retain in mouth as long as possible before swallowing. Shake suspension well. Use calibrated dropper provided.

• Do not mix oral suspension in foods.

• To use powder for extemporaneous compounding, reconstitute ⅛ tsp (500,000 units) in half glass of water and stir well. Use immediately; do not store. Can be administered in form of flavored frozen popsicle.

[edit] Storage/Stability

Refrigerate vaginal tablets. Store oral suspension in refrigerator. Protect from heat, light, moisture, and air.

[edit] See Also

[edit] References