Nuclear receptor subfamily 3 group C member 2; Fragment;

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Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

[edit] Source Organism

Gallus gallus (Chicken).

[edit] Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.

[edit] Subcellular Localization

Cytoplasm (By similarity). Nucleus (By similarity). Note=Cytoplasmic and nuclear in the absence of ligand, nuclear after ligand-binding (By similarity).

[edit] Developmental Stage

[edit] Similarity

Belongs to the nuclear hormone receptor family. NR3 subfamily.

[edit] Post translational Modification

[edit] Function

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity).