Nuclear receptor subfamily 1 group D member 3, isoform B;

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Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

[edit] Source Organism

Drosophila melanogaster (Fruit fly).

[edit] Taxomomy

Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila; Sophophora.

[edit] Subcellular Localization

Nucleus (Potential).

[edit] Developmental Stage

In mid instar larvae salivary glands, levels increase during puff stage 1, then remain relatively constant until the premetamorphic pulse of ecdysone at puff stage 5. Levels increase again in late larvae at puff stages 9-10. At puff stage 1 expression is also seen in the gut. Levels are low in the gut, Malpighian tubules, fat body and wing disks between stages 1 and 11.

[edit] Similarity

Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.

[edit] Post translational Modification

[edit] Function

Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.