Nuclear receptor subfamily 1 group D member 3, isoform A;

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Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

[edit] Source Organism

Drosophila melanogaster (Fruit fly).

[edit] Taxomomy

Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila; Sophophora.

[edit] Subcellular Localization

Nucleus (Potential).

[edit] Developmental Stage

In mid instar larvae salivary glands, levels are low during puff stage 1, increase during puff stages 2-4 and diminish from stage 5 onwards. In prepupae, isoform A is the predominant form during puff stage 19 and the transition to stage 20. By stage 3 it is present in the gut, Malpighian tubules and the fat body, levels persist beyond stage 11.

[edit] Similarity

Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.

[edit] Post translational Modification

[edit] Function

Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.