Growth hormone-releasing factor (GRF) (Growth hormone-releasing hormone) (GHRH)

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[edit] Description

Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus.

GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophyseal portal circulation to the anterior pituitary gland where it stimulates growth hormone (GH) secretion by stimulating the growth hormone releasing hormone receptor. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleep directly. <ref>Obál F, Krueger J (2001). "The somatotropic axis and sleep.". Rev Neurol (Paris) 157 (11 Pt 2): S12–5. PMID 11924022. </ref>

[edit] Relationship of GRH & somatostatin

The actions of GHRH are opposed by "growth-hormone-inhibiting hormone", more commonly termed somatostatin.

Somatostatin is released from neurosecretory nerve terminals of periventricular somatostatin neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary where it inhibits GH secretion. Somatostatin and GHRH are secreted in alternation, giving rise to the markedly pulsatile secretion of GH.

[edit] Sequence

The amino acid sequence of GHRH is:

COOH - Tyr - Ala - Asp - Ala - Ile - Phe - Thr - Asn - Ser - Tyr - Arg - Lys - Val - Leu - Gly - Glu - Leu - Ser - Ala - Arg - Lys - Leu - Leu - Gln - Asp - Ile - Met - Ser - Arg - Glu - Gln - Gly - Glu - Ser - Asn - Gln - Glu - Arg - Gly - Ala - Arg - Ala - Arg - Leu - NH2

[edit] Source Organism

Clarias macrocephalus (Thai catfish).

[edit] Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;Clariidae; Clarias.

[edit] Subcellular Localization

Secreted protein.

[edit] Developmental Stage

[edit] Similarity

Belongs to the glucagon family.

[edit] Post translational Modification

[edit] Function

Primary role of GHRH is to release GH from the pituitary

[edit] GeneID

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