Germ cell nuclear factor;GCNF;xGCNF
From DrugPedia: A Wikipedia for Drug discovery
Contents |
[edit] Source Organism
Xenopus laevis (African clawed frog).
[edit] Taxomomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;Xenopodinae; Xenopus; Xenopus.
[edit] Subcellular Localization
Cytoplasm. Nucleus.
[edit] Developmental Stage
Isoform Oo is expressed both maternally and zygotically, being predominantly expressed in oocytes and embryos before the midblastula transition but present at later stages at very low levels. Isoform Em is expressed zygotically between late gastrula stage and late tailbud stage 30, being predominant during tailbud stages.
[edit] Similarity
Belongs to the nuclear hormone receptor family. NR6 subfamily. Contains 1 nuclear receptor DNA-binding domain.
[edit] Post translational Modification
[edit] Function
Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3'. Required for anterior-posterior patterning during organogenesis. Acts with chordin to play a role in patterning the midbrain-hindbrain. Isoform Em is required for integrin-mediated cell matrix interaction during neurulation and for the morphogenetic movements leading to formation of the neural tube. Also mediates the effect of retinoic acid on primary neurogenesis.
