CarboDB Type 1b polysaccharide 2411
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Type 1b polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Streptococcus Group B
[edit] Basic Structure
N/A
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
H36B vaccine that had been treated with 2 N acetic acid at 80C for 10 min to largely desialylate the type lb polysaccharide.
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab SIbD2
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, indirect immunofluorescence
[edit] Cross-reactivity
This Mab reacted specifically with the de-sialylated form of the type 1b polysaccharide. This Mab cross-reacts with some oligosaccharides in human milk and certain fetal antigens
[edit] Proposed epitopes
lacto-N-tetraose residues seemed to be the immunodominant epitope
[edit] Proposed Utility
This Mab will help in the development of appropriate vaccines against GBS that would include the possibility of inducing major cross-reactions with human glycoconjugates
