CarboDB Phosphocholine 1041
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Phosphocholine
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Pneumococcal strain WU(12)
[edit] Basic Structure
Phosphocholine (PC) is an intermediate in the synthesis of phosphatidylcholine in tissues. Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP + Choline into Phosphocholine and ADP
[edit] Proposed functions
Phosphocholine is determinant of lipotechoic acids of Gram positive bacteria
[edit] Antigenic Nature used to produce antibodies
Cell extract and heat killed Pneumococcal strain EF3296.
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
SR4W1
[edit] Antibody type and class
IgG2a
[edit] Assay System
Blood bactericidal assay, hemolytic activity
[edit] Cross-reactivity
N/A
[edit] Proposed epitopes
Phosphocholine
[edit] Proposed Utility
Monoclonal antibody SR4W1 can protect mice against Pneumococcal infections.
