CarboDB O-polysaccharide 2319
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Shigella flexneri serotype 1b
[edit] Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Heat killed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MASF I
[edit] Antibody type and class
IgG1
[edit] Assay System
immunoblotting, enzyme-linked immunosorbent assay (ELISA), hemagglutination, and coagglutination
[edit] Cross-reactivity
The type I O antigen-specific antibodies were shown to bind exclusively to S. flexneri serotypes la and lb in ELISA
[edit] Proposed epitopes
The α-D-Glcp-(1-->4)-β-D-GlcpNAc disaccharide in the repeating unit of the O-antigen is the immunodominant region to which these antibodies bind
[edit] Proposed Utility
This Mab can be used for detection and identification of shigella flexneri species
