CarboDB O-polysaccharide 2043
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Pseudomonas aeruginosa
[edit] Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Formalin killed whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 18-19
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA, immunoblotting, ouchterlony immunodiffusion
[edit] Cross-reactivity
"This Mab cross-reacted with Serotypes O2, O5 and O16"
[edit] Proposed epitopes
In addition to the O-antigen part, this Mab also binds to the core region
[edit] Proposed Utility
This Mab helps us shed some light on the nature of O-specific and common epitopes in the LPS of P. aeruginosa
