CarboDB O-polysaccharide 2040
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Pseudomonas aeruginosa Serotype O2
[edit] Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Formalin killed whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MF71-3
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, immunoblotting, ouchterlony immunodiffusion
[edit] Cross-reactivity
This Mab was specific to serotype O2
[edit] Proposed epitopes
The epitope consisted of the L-guluronic acid-(α1-->3)-D-FucNAc(β1-->4) portion of the O2-antigen
[edit] Proposed Utility
This Mab helps us shed some light on the nature of O-specific and common epitopes in the LPS of P. aeruginosa
