CarboDB O-polysaccharide 1259
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Campylobacter fetus 554
[edit] Basic Structure
The LPS molecule of C. fetus is composed of three distinct structural domains: a hydrophobic lipid A portion which forms the outer leaflet of the outer membrane and which contains the endotoxic activity, a low-molecular-weight oligosaccharide core complex, and a variable-length O-specific polysaccharide chain with repeating oligosaccharide units (O-antigen)
[edit] Proposed functions
The LPS O-antigens are the basis of the C. fetus heat-stable serotyping Scheme
[edit] Antigenic Nature used to produce antibodies
a mixture (1:1) of C. fetus 553 and 554 formalin-killed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab M1177
[edit] Antibody type and class
IgG1
[edit] Assay System
Indirect ELISA, immunoblotting,
[edit] Cross-reactivity
This antibody was specific to O antigen of C. fetus 554 and did not cross-react with C. fetus 553
[edit] Proposed epitopes
Acetylated groups seem to be an important part of the epitope
[edit] Proposed Utility
This Mab can be used to serotype C. fetus strains
