CarboDB O-polysaccharide 1240

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

O-polysaccharide

[edit] Carbohydrate Class

O-polysaccharide [LPS]

[edit] Source Microbe

Brucella melitensis Rev1

[edit] Basic Structure

O-polysaccharide consists of an unbranched linear homopolymer of 10 to 100 α-1,2-linked 4-formamido-4,6-dideoxy-D-mannose (N formylperosamine) residues. The O-polysaccharide is covalently linked to a core oligosaccharide

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Whole B. melitensis Cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 15B1G10

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA

[edit] Cross-reactivity

This Mab was specific to A and M strains of Brucella and did not cross-react with S-LPSs of S. urbana, Vibrio cholerae and E. coli O:157 but bound better to M-dominant S-LPS than to A-dominant S-LPS

[edit] Proposed epitopes

This Mab was specific to the C epitope

[edit] Proposed Utility

This Mab helped in the epitope strucure elucidation

[edit] Weblink

PubMed Central

[edit] External Links

• Link to CarboDB database