CarboDB O-polysaccharide 1123
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Actinobacillus pleuropneumoniae serotype 9
[edit] Basic Structure
The structure consists of trisaccharide backbone randomly substituted by N-acetyl-β-D-glucosamine end groups (to the extent of 25%)
[edit] Proposed functions
LPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus
[edit] Antigenic Nature used to produce antibodies
formalin-fixed A. pleuropneumoniae serotype 9 cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Polysera
[edit] Antibody type and class
N/A
[edit] Assay System
ELISA
[edit] Cross-reactivity
This antibody cross-reacted with serotypes 1 and 12. also cross-reacted with deaminated Serotype1 O-PS
[edit] Proposed epitopes
The epitope was deduced to contain the terminal nonreducing -D-Glc NAc residues. A second epitope was said to be directed to linear regions of the backbone polymer
[edit] Proposed Utility
This antisera not only helped in serotyping analysis but also helped in deducing the epitopes recognized
