CarboDB O-polysaccharide 1121
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Actinobacillus pleuropneumoniae serotype 1 strain Shope 4074
[edit] Basic Structure
O chains of LPS of are composed of repeating tetrasaccharide units with identical trisaccharide residues forming a common backbone
[edit] Proposed functions
LPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus
[edit] Antigenic Nature used to produce antibodies
formalin-fixed A. pleuropneumoniae serotype 1 cells (strain Shope 4074]
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 5D6
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, Rapid Dot ELISA and Slide agglutination test
[edit] Cross-reactivity
This antibody cross-reacted with reference strains of serotypes 1 and 11
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab may provide reliable specific tools for rapid serological diagnosis of animals infected with serotypes 1 and 11 by inhibition or competition ELISA. Moreover, these mAbs could be useful as a complementary specific reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotypes 1 and 11
