CarboDB Lipopolysaccharide 2312
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Shigella flexneri serotype 5a
[edit] Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
mIgA
[edit] Antibody type and class
IgA
[edit] Assay System
ELISA, In Vivo Protection Experiments
[edit] Cross-reactivity
The antibody recognized 5a LPS but failed to react with 2a LPS and Y LPS
[edit] Proposed epitopes
mlgA was directed against a serotype specific epitope comprising at least the glucosyl residue specifically linked to the central rhamnose of the basic structure of the S. flexneri LPS
[edit] Proposed Utility
This Mab protected the animals against subsequent intranasal challenge with S. flexneri serotype 5a
