CarboDB Lipopolysaccharide 2229
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Salmonella minnesota R 595 [Re]
[edit] Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : α-Kdop-(2-8)-α-Kdop-(2-->4)-Kdo
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Heat killed bacteria
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MASM3
[edit] Antibody type and class
IgG2b
[edit] Assay System
Enzyme immunoassay, ELISA
[edit] Cross-reactivity
This Mab cross-reacted with Salmoneela typhimurium SL1102 Re chemotype LPS
[edit] Proposed epitopes
3-deoxy-D-mannooctulosonic acid [KDO] residues at the terminal non-reducing ends seemed to be the part of the epitope
[edit] Proposed Utility
This Mab would help elucidate the Kdo LPS domain structure
