CarboDB Lipopolysaccharide 2174
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Salmonella paratyphi A
[edit] Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Parp-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp [branched to α-D-Glcp-(1-->4)] -(1-
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Formalin fixed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MO2
[edit] Antibody type and class
IgG1
[edit] Assay System
ELISA, immunoblotting
[edit] Cross-reactivity
This Mab was specific to lipopolysaccharide of Salmonella paratyphi A, and did not react against lipopolysaccharides of other Salmonella serogroups, including those of serogroups B, C, D, E, and L
[edit] Proposed epitopes
Dideoxyhexose residues are believed to be the immunodominant epitope for Mab M02
[edit] Proposed Utility
This Mab can facilitate the routine identification of salmonella and detailed studies of their lipopolysaccharides
