CarboDB Lipopolysaccharide 2167
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Salmonella typhimurium
[edit] Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Abep-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
heated, alcohol-acetone-extracted Sabnonella newport CDC 50 antigen
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 32-1-E3
[edit] Antibody type and class
IgG3
[edit] Assay System
Enzyme immunosorbent assay, immunoblotting
[edit] Cross-reactivity
This Mab cross-reacts with Sablonella groups C2 (0:6,8) and C3 (0:-,8) but not with those from any other serogroup tested
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
The MAb agglutinated with all strains of Salmonella serogroups C2 and C3 tested but not with other bacteria. The MAb is useful as a replacement for absorbed, polyclonal, single-factor 0:8 antiserum to discriminate Salmonella serogroups C2 and C3 from serogroup Cl
