CarboDB Lipopolysaccharide 1453

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Francisella tularensis

[edit] Basic Structure

The O-antigen consisted of the following residues : -2)βD-Quip4NFo(1-->4)α-D-GalpNAcA6NH2(1-->4)α-D-GalpNAcA6NH2(1-->3)βDQuipNAc(1-

[edit] Proposed functions

It is an important virulence factor

[edit] Antigenic Nature used to produce antibodies

heat-killed F. tularensis

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab FT14

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA and immunoblotting

[edit] Cross-reactivity

This Mab was unique to F. tularensis

[edit] Proposed epitopes

O-side chains seems to be an important part of the epitope

[edit] Proposed Utility

This Mab would help to detect the organism in environmental samples and clinical specimens

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to CarboDB database