CarboDB Lipopolysaccharide 1166
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Bordetella pertusis 1414
[edit] Basic Structure
B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B
[edit] Proposed functions
The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties
[edit] Antigenic Nature used to produce antibodies
B. pertusis Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 60.5
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA and Immunostaining
[edit] Cross-reactivity
This Mab did not cross-react with the B. pertusis variant strain A102 but cross-reacted with a B. bronchiseptica LPS
[edit] Proposed epitopes
The epitope was proposed to be terminal region of a distal trisaccharide GlcNAc-->2,3-NAcManA-->FucN(Ac)Me consisting of Nacetylated amino sugars. A next carbohydrate unit (2,3-NAcManA) may be partially involved in the recognized epitope
[edit] Proposed Utility
This Mab can be useful for rapid typing of Bordetella in clinical isolates and can be used to detect antigenic modifications in LPSs from variant B. pertassis strains, or from related Bordetella species (B. parapertassis, B. bronchiseptica
