CarboDB Lipopolysaccharide 1081

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Escherichia coli O18A

[edit] Basic Structure

The O-polysaccharide part consists of the following residues : -2)α-L-Rhap(1-->6)α-D-Glcp(1-->4)α-D-Galp [branched to β-D-GlcpNAc(1-->3)] (1-->3)α-D-GlcpNAc [branched to α-D-Glcp(1-->6)] (1-

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

boiled E. coli 018A bacteria

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab PL4

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, immunoblotting and Bacterial agglutination tests, competitive inhibition assays

[edit] Cross-reactivity

This Mab was specific to E. coli strain 018A and 018A2 but cross-reacted with S. marcescens 08 LPS

[edit] Proposed epitopes

N-acetyl-D-glucosamine seemed to be a part of the epitope

[edit] Proposed Utility

N/A

[edit] Weblink

[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC261100 &tool=pmcentrez&rendertype=abstract PubMed Central]

[edit] External Links

• Link to CarboDB database