CarboDB Lipopolysaccharide 1072

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Escherichia coli Olll:B4

[edit] Basic Structure

N/A

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 5B10

[edit] Antibody type and class

IgG2a

[edit] Assay System

ELISA, immunoblotting, radioimmunoassay, invivo protection assay

[edit] Cross-reactivity

This antibody did not bind to LPS from E. coli 55, an Rc mutant of E. coli 011 1:B4 that lacks both the O-antigen and outer core sugars. 5B10 did not crossreact with LPS from several other E. coli strains

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab was able to protect mice from a lethal challenge of E. coli 0111:B4 organisms

[edit] Weblink

[http://www.ncbi.nlm.nih.gov/pubmed/3298431 ?dopt=Abstract' PubMed]

[edit] External Links

• Link to CarboDB database