CarboDB Lipopolysaccharide 1040
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Chlamydia spp.
[edit] Basic Structure
LPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
[edit] Proposed functions
LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
[edit] Antigenic Nature used to produce antibodies
Formalin killed L2 EBs
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab L21-6
[edit] Antibody type and class
IgG3
[edit] Assay System
Immunobloting
[edit] Cross-reactivity
This antibody was cross-reactive with Re LPS of S.typhimurium.
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
Monoclonal antibody L21-6 recognizes chlamydal genus specific epitope.
