CarboDB Lipophosphoglycan 1547
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipophosphoglycan
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Leishmania mexicana
[edit] Basic Structure
LPG contains [PO4-->6Gal(β1-->4)Man(α1)] phosphosaccharide repeats linked to a conserved phosphosaccharide core and a conserved lyso alkylphosphatidylinositol residue. In contrast to L. donovani LPG, which exclusively contains the phosphodisaccharide repeats
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
concanavalin A (ConA)-binding membrane components from L. mexicana
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab L7.25
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, immunoblotting
[edit] Cross-reactivity
This Mab cross-reacted with a highly glycosylated protein - acid phosphatase
[edit] Proposed epitopes
The epitope was proposed to consist of phosphosaccharide repeats or the sugar residues forming the cap at the non-reducing end
[edit] Proposed Utility
the epitopes recognized by this Mab have been localized in promastigotes and infected macrophages
