CarboDB Lipoologosaccharide band A of the LPS 1171
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipoologosaccharide band A of the LPS
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Bordetella pertusis
[edit] Basic Structure
B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B
[edit] Proposed functions
The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties
[edit] Antigenic Nature used to produce antibodies
N/A
[edit] Carrier Name
N/A
[edit] Conjugation Method
N/A
[edit] Antibodies
Mab G10F8C3
[edit] Antibody type and class
IgG3
[edit] Assay System
Immunoblotting, Protein A sepharose affinity chromatography, bactericidal assays
[edit] Cross-reactivity
This antibody was specific to B. pertusis strains
[edit] Proposed epitopes
This Mab reacts with the core oligosaccharide moeity
[edit] Proposed Utility
This Mab exhibits complement dependent bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition it was effective in reducing colonization by B. pertussis in both the lungs and tracheas of mice after aerosol infection
