CarboDB LacdiNAc 2235
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
LacdiNAc
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Schistosoma mansoni
[edit] Basic Structure
This carbohydrate consists of N-linked glycans containing GalNAc-β-1-->4GLcNAc
[edit] Proposed functions
These carbohydrate structures are mainly involved in immune evasion
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Bovine serum albumin
[edit] Conjugation Method
The spacer linked oligosaccharides were converted to their N-hydroxysuccinimido-ester complexes and conjugated to amino groups on BSA
[edit] Antibodies
Mab 259-2A1
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA, indirect immunfluorescence and surface plasmon resonance
[edit] Cross-reactivity
This Mab was highly specific and did not show cross-reactivity to other carbohydratge epitopes
[edit] Proposed epitopes
This Mab was directed to LacdiNAc residues that were mainly present on the tegument of adult worms, on miracidia, and on the oral sucker of cercariae
[edit] Proposed Utility
This Mab may lead to a better understanding of the function of glycans
