CarboDB Heptasaccharide motif (M2) of Glucurunoxylomannan 1493

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Heptasaccharide motif (M2) of Glucurunoxylomannan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Cryptococcus neoformans Serotype D [strain 24067]

[edit] Basic Structure

The heptasaccharide consists of two M2 triad repeats and mannose residue. The M2 repeat was selected because it is commonly found in GXM of serotype A strain

[edit] Proposed functions

Glucurunoxylomannan is an antiphagocytic determinant ; an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Human serum albumin

[edit] Conjugation Method

N/A

[edit] Antibodies

Mab 1E3

[edit] Antibody type and class

IgM

[edit] Assay System

Immunofluorescence and phagocytosis assays

[edit] Cross-reactivity

This antibody cross-reacted with Serotype D

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

N/A

[edit] Weblink

PubMed

[edit] External Links

• Link to CarboDB database