CarboDB Glycoprotein GP72 2486

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Glycoprotein GP72

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Trypanosoma cruzi Z2 Esmeraldo/3

[edit] Basic Structure

GP72 is a 72-kilodalton cell surface glycoprotein found on epimastigotes and metacyclic trypomastigotes

[edit] Proposed functions

GP72 may regulate T. cruzi morphogenesis in the insect vector

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 8G2 B9

[edit] Antibody type and class

IgG2a

[edit] Assay System

ELISA, immunoblotiing, indirect immunofluorescence

[edit] Cross-reactivity

This Mab cross-reacted with T. cruzi BOL Z2, and Z3 but did not react with Z1

[edit] Proposed epitopes

This Mab binds to phosphorylated sugar side chains, which comprise 85% of GP72 carbohydrate and contain ribose, xylose, and fucose

[edit] Proposed Utility

Anti-T. cruzi monoclonal antibodies are considered to have important applications to epidemiological studies and the improved diagnosis and prognosis of Chagas' disease

[edit] Weblink

PubMed

[edit] External Links

• Link to CarboDB database