CarboDB Capsular polysaccharide 1971
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Streptococcus pneumoniae strain 6B
[edit] Basic Structure
The capsular polysaccharide consists of the following residues : -2)-α-D-Galp-(1-->3)-α-D-Glcp-(1-->3)-α-L-Rhap-(1-->4)-D-Rib-ol-(5-P-
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Tetanus toxoid
[edit] Conjugation Method
The oligosaccharide was derivatized with adipic acid dihydrazide and coupled to tetanus toxoid
[edit] Antibodies
Mab 10H8
[edit] Antibody type and class
IgG1
[edit] Assay System
Enzyme Inhibition Assay, colony blotting, Opsonophagocytosis assay
[edit] Cross-reactivity
This Mab reacted with polysaccharides from 11A, 19F and 23F strain but did not recognize type 6A polysaccharide
[edit] Proposed epitopes
disaccharide rhamnose-(1-->4)-ribitol phosphate residues seemed to be the part of the epitope
[edit] Proposed Utility
N/A
