Bioinformatics Resource for Swine Flu : Suggestions invited
From DrugPedia: A Wikipedia for Drug discovery
Outbreak of infectious diseases is one of the major problem world-wide; for example swine flu. In post genomics ear bioinformatics may provide important information for combating infectious diseases. Unfortunately bioinformaticians world-wide are working at component level not at system or organism level. It means bioinformaticians are working on problems like protein structure prediction; epitope prediction; comparative genomics; searching drug targets; docking; inhibitor design etc. In addition bioinformaticians works in passive form not in active form, it means they develop/provide tools/techniques and expect that biologist will use their tools.
Our group is working in bioinformatics at component level (Raghava's Group), now we wish to provide information at organism level. In simple world we wish to provide comprehensive information on influenza A (H1N1) virus, responsible for swine flu. We are creating Swine flu datbase and drugpedia. Our aim is to provide as much information as possible to community under open source so that community may fight against this disease efficiently. We are inviting suggestion from community, what type of bioinformatics resources community need. Following are few suggestions. I will highly appreaciate if you add more suggestion on this site or send your suggestions to me on mailto:[email protected]
- Nucleotide and proteins sequence of each strain;
- Preferred codon usage at sequence and at strain level
- Prediction of expression of each gene based on codon usage
- Designing of primer for each gene
- Mapping of restriction sites
- Protein structure of each protein based on homology
- Pockets or active sites in proteins and docking of desired small molecule and peptides
- Mapping of Epitopes (T-cell, B-cell) in proteins
- Variable and conserved regions in protein of sequences
