Beta-2 adrenergic receptor

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

[edit] Source Organism

Bos taurus (Bovine).

[edit] Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.

[edit] Subcellular Localization

Cell membrane; multi-pass membrane protein.

[edit] Developmental Stage

[edit] Similarity

Belongs to the G-protein coupled receptor 1 family.

[edit] Post translational Modification

Palmitoylated; may reduce accessibility of Ser-345 and Ser- 346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity). Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA- mediated phosphorylation seems to facilitate phosphorylation by BARK (By similarity).

[edit] Function

Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).