PolysacDB O-polysaccharide 2293
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Shigella dysenteriae
[edit] Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Heat killed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 3707 E9
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA and immunoblotting
[edit] Cross-reactivity
N/A
[edit] Proposed epitopes
rhamnopyranosyl-α-( 1-->2)-galactopyranosyl disaccharide seemed to be the major antigenic determinanant
[edit] Proposed Utility
This Mab can help in the identification of immunodominant epitope in the O-antigen of Shigella dysenteriae LPS
