PolysacDB Capsular polysaccharide 2604
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Cryptococcus neoformans Serotype C
[edit] Basic Structure
The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
[edit] Proposed functions
The capsular polysaccharide is an important virulence factor
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Sheep erythrocytes
[edit] Conjugation Method
The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature
[edit] Antibodies
Mab 3C2
[edit] Antibody type and class
N/A
[edit] Assay System
ELISA and Immunodiffusion
[edit] Cross-reactivity
This antibody cross-reacted with Serotype A,B,C and D serotypes
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
used to differentiate various strains of all serotypes. This monoclonal antibody promoted opsonization of Cryptococcus cells
