PolysacDB Capsular polysaccharide 1822
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Neisseria meningitidis group C
[edit] Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
[edit] Proposed functions
It is an important virulence factor
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Tetanus toxoid
[edit] Conjugation Method
The oligosaccharide was activated using NaIO4 at 4C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37C for 5 days
[edit] Antibodies
Mab C2/706.12
[edit] Antibody type and class
IgG1
[edit] Assay System
ELISA
[edit] Cross-reactivity
This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide and also cross-reacted with E. coli K92 capsular polysaccharide
[edit] Proposed epitopes
α(2-->9)-linked sialic acid backbone seemed to be the part of the epitope
[edit] Proposed Utility
This Mab can be used for studying the capsular polysaccharide immunogenicity
