Drugs in clinical trial
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A table showing drug in clinical trial for Alzheimer's disease
| Name | OTHER NAMES | FDA PHASE |
|---|---|---|
| AAB-001 | Bapineuzumab, Humanized monoclonal anti-Aβ antibody | Phase III |
| ACC-001 | Phase I | |
| Acetyl-l-carnitine HCI | ALCAR | Discontinued |
| AF 102B | cevimeline HCL, Evoxac™ | Discontinued |
| Alpha-tocopherol | Vitamin E | Discontinued |
| Alzhemed™ | 3-amino-1-propanesulfonic acid, 3-aminopropylsulfonic acid, 3-APS, homotaurine, NC-531, Tramiprosate | Phase III |
| AN 1792 | AIP 001 | Discontinued |
| Atorvastatin | Lipitor™ | Phase II/IIa/IIb |
| AZD3480 | ispronicline, TC-1734 | Phase II/IIa/IIb |
| Besipirdine HCl | HP 749 | Discontinued |
| Beta- & Gamma-Secretase Inhibitors | Preclinical | |
| Cerebrolysin | Approved outside U.S. | |
| Clioquinol | iodochlorhydroxyquin, PBT-1 | Discontinued |
| COGNIShunt™ | Phase II/IIa/IIb | |
| CX516 | Ampalex | Phase II/IIa/IIb |
| Dapsone | Avlosulfon | Phase II/IIa/IIb |
| Dimebon | 3,6-dimethyl-9-(2-methyl-pyridyl-5)-ethyl-1,2,3,4-tetrahydro-γ-carboline dihydrochloride | Phase II/IIa/IIb |
| Docosahexanoic acid (DHA) | Omega 3 fatty acids | Phase III |
| Donepezil | Aricepts™ | FDA approved |
| Eptastigmine | MF 201 | Discontinued |
| Estrogen | Premarin™ | Phase III |
| Exelon™ | Rivastigmine tartrate | FDA approved |
| Flurizan™ | MPC-7869, r-flurbiprofen, tarenflurbil | Discontinued |
| Galantamine | Reminyl™ | FDA approved |
| Huperzine A | Cerebra capsule, Pharmassure Memorall capsule | Phase II/IIa/IIb |
| Ibuprofen | Advil™, Motrin™, Nuprin™ | Phase III |
| Idebenone | Discontinued | |
| Intravenous Immunoglobulin | IVIg | Phase II/IIa/IIb |
| Leuprolide | Leuprolide acetate | Phase III |
| Linopirdine | DuP996 | Discontinued |
| LU25-109 | Discontinued | |
| LY450139 Dihydrate | hydroxylvaleryl monobenzocaprolactam | Phase III |
| Melatonin | Not FDA regulated | |
| MEM 1003 | Phase II/IIa/IIb | |
| Memantine | Ebixa™, Namenda™ | FDA approved |
| Metrifonate | Discontinued | |
| Milameline | CI 979 | |
| MKC-231 | Phase II/IIa/IIb | |
| NAME: Naproxen | Aleve™, Anaprox™, Naprosyn™ | Phase III |
| Nefiracetam | Phase II/IIa/IIb | |
| NeoTrofin | AIT-082 | Phase II/III |
| Neramexane | 1-amino-1,3,3,5,5-pentamethyl-cyclohexane hydrochloride, MRZ 2/579 | Phase III |
| Nerve Growth Factor Gene Therapy | Nerve Growth Factor | Phase II/IIa/IIb |
| NGX267 | AF267B | Phase I |
| NS2330 | Phase II/IIa/IIb | |
| PBT2 | Phase II/IIa/IIb | |
| Phenserine | Inactive | |
| Physostigmine Salicylate | Synapton | Discontinued |
| Propentofylline | HWA 285 | |
| PRX-0314 | 7-isopropyl-6-oxo-5(3-piperidin-1-yl-propylcarbamoyl)-6,7-dihydro-thieno[2,3-b]pyridine-4-olate, potassium salt | Phase I |
| Rofecoxib | Vioxx™ | Phase III |
| Rosiglitazone | 5-[[4-[2-(methyl-pyridin-2-yl-amino)ethoxy]phenyl]methyl]thiazolidine-2,4-dione, AVANDIA®, Rosiglitazone maleate | Phase III |
| Sabeluzole | R58735 | Discontinued |
| SB 202026 | Memric, Sabcomeline | Discontinued |
| SGS-742 | CGP-36742, DVD-742 | Phase II/IIa/IIb |
| Simvastatin | Zocor® | Phase III |
| Statins | Phase II/IIa/IIb | |
| Suritozole | MD 26,479 | Discontinued |
| Tacrine | Cognex™ | FDA approved |
| Valproate | Depakene (valproic acid or sodium valproate), Depakote (divalproex sodium) | Phase III |
