Desoxycortone

From DrugPedia: A Wikipedia for Drug discovery

Desoxycorticosterone (11-deoxycorticosterone) is a mineralocorticoid<ref>Template:DorlandsDict</ref> secreted from Zona reticularis and Zona fasciculata of the adrenal gland.

Pubchem(6166)

21-Hydroxypregn-4-ene-3,20-dione. Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.

KEGG Pathway(C03205,D07792)

C21-Steroid hormone metabolism

Activity Adrenal cortex hormone, mineralocorticoid

**List of PDB files having Deoxycorticosterone as a Ligand:**
MMDB ID	PDB ID	Reference
33237	1Y9R	Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin MECrystal structure of a mutant mineralocorticoid receptor responsible for hypertensionNat. Struct. Mol. Biol. v12, p.554-555
34430	2AA7	Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SPA ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptorJ. Biol. Chem. v280, p.31283-31293
59380	2Q3Y	Ortlund EA, Bridgham JT, Redinbo MR, Thornton JWCrystal structure of an ancient protein: evolution by conformational epistasisScience v317, p.1544-1548

**Physiochemical properties of Deoxycorticosterone:**
Physical Property	Value	Units	Temp (deg C)	Source
Melting Point	141.5	deg C		EXP
log P (octanol-water)	2.88	(none)		EXP
Water Solubility	59.5	mg/L	37	EXP
Vapor Pressure	2.85E-10	mm Hg	25	EST
Henry's Law Constant	1.01E-08	atm-m3/mole	25	EST
Atmospheric OH Rate Constant	1.07E-10	cm3/molecule-sec	25	EST

**Toxicity:**
Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	unreported	1gm/kg (1000mg/kg)		Journal of Medicinal Chemistry. Vol. 7, Pg. 673, 1964.

[edit] Synthesis

In the cytosol of the mitochondrion, pregnenolone is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the endoplasmic reticulum. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively.

[edit] Forms

Desoxycorticosterone is commonly found in two forms: the acetate salt (desoxycorticosterone acetate, or DOCA) and the pivalate salt (desoxycorticosterone pivalate).

[edit] Uses

Both forms are given as intramuscular injections as replacement therapy for Addison's disease. This disease is marked by insufficient adrenal function, including low mineralocorticoid levels.

Desoxycorticosterone pivalate is sold for veterinary use by Novartis under the brand name Percoten.